Date of Award
2019
Publisher
North Dakota State University
Document Type
Thesis
Degree Awarded
Master of Science (MS)
Program
Biomedical Engineering
Department
Mechanical Engineering
College
Engineering
Faculty Advisor
Wang, Yechun
Description
Three-dimensional spheroid arrays represent in vivo activity better than conventional 2D cell culturing. A high-throughput microfluidic chip may be capable of depositing cells into spheroid arrays, but it is difficult to regulate the path of individual cells for deposition. Droplets that encapsulate cells may aid in facilitating cell delivery and deposition in the return bend of a microfluidic chip. In this study, a low-cost method for fabricating polymer-cast microfluidic chips has been developed for rapid device prototyping. Computational fluid dynamic (CFD) simulations were conducted to quantify how a change in geometry or fluid properties affects the dynamics of a droplet. These simulations have shown that the deformation, velocity, and trajectory of a droplet are altered when varying the geometry and fluid properties of a multiphase microfluidic system. This quantitative data will be beneficial for the future design of a microfluidic chip for cell deposition into 3D spheroid arrays.
Recommended Citation
Singh, John-Luke Benjamin, "Design and Fabrication of Micro-Channels and Numerical Analysis of Droplet Motion Near Microfluidic Return Bends" (2019). Mechanical Engineering and Applied Mechanics. 125.
https://digitalcommons.ndsu.edu/mech-eng-applied-mechanics/125
Rights
NDSU policy 190.6.2
Rights Link
https://www.ndsu.edu/fileadmin/policy/190.pdf
Author ORCID Identifier
0000-0002-3758-6338
Handle Identifier
https://hdl.handle.net/10365/31706