Date of Award

2014

Publisher

North Dakota State University

Document Type

Thesis

Degree Awarded

Master of Science (MS)

Program

Animal Sciences

Department

Animal Sciences

College

Agriculture, Food Systems and Natural Resources

Faculty Advisor

Vonnahme, Kimberly A.

Description

We hypothesized that global maternal nutrient restriction during early and mid-gestation followed by realimentation in pregnant beef cows would alter placental arterial vascular function. We tested changes in placental caruncular (CAR) and cotyledonary (COT) arterial sensitivity to bradykinin (BK), a potent vasodilator. Cows were randomly assigned to be nutrient restricted for 55 or 110 during early to mid pregnancy. On d 85, 140, and 254 cows were euthanized and CAR and COT arteries were isolated. Maternal nutrient restriction during early and mid-gestation allowed for placental compensation to overcome the loss of nutrients while realimentation returned placental arterial vosoactivity similar to control cows in response to BK. Further, CAR and COT placental arteries may respond to BK induced vasodilation through different pathways which is important when considering possible therapeutics for compromised pregnancies.

Rights

NDSU policy 190.6.2

Rights Link

https://www.ndsu.edu/fileadmin/policy/190.pdf

Handle Identifier

https://hdl.handle.net/10365/26993

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