Date of Award

2020

Publisher

North Dakota State University

Document Type

Thesis

Degree Awarded

Master of Science (MS)

Program

Biomedical Engineering

College

Engineering

Faculty Advisor

Nawarthna, Dharmakeerthi

Description

The number of new cancer cases is projected to rise to 23.6 million by 2030 according to the National Cancer Institute. Obesity & cardiovascular diseases are among the leading causes of death worldwide according to recent reports. Biomarkers— any molecules found within a human body that can be used to monitor an individual's health — have been shown to play a significant role in the detection of cancer, obesity, and cardiovascular diseases. Recent studies have shown that in the diagnosis and screening of various human diseases, including cancer, obesity and cardiovascular diseases, circulating microRNAs (miRNAs) are important biomarkers. A crucial roadblock to using microRNA in screening applications is the lack of effective and low-cost microRNA detection. To address this issue, in this study, we have developed a viable method that combines the dielectrophoresis and electrical impedance. Results show this approach can measure very small concentrations of label-free microRNAs (1pM).

Rights

NDSU policy 190.6.2

Rights Link

https://www.ndsu.edu/fileadmin/policy/190.pdf

Author ORCID Identifier

0000-0003-3240-431X

Handle Identifier

https://hdl.handle.net/10365/31880

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