Date of Award
2009
Publisher
North Dakota State University
Document Type
Thesis
Degree Awarded
Master of Science (MS)
Program
Chemistry and Biochemistry
Department
Chemistry and Biochemistry
College
Science and Mathematics
Faculty Advisor
Sibi, Mukund P.
Description
A convenient protocol for functionalization of ~-pyrones has been developed. Conjugate radical addition and tandem addition-trapping protocols allowed accessing highly substituted pyrones in a single operation with high selectivity. Different radical sources were utilized in the reaction. nOe experiments were performed to confirm the relative stereochemistry of the substituents in the conjugate addition products. Initial studies on the enantioselectivity of the reaction were carried out. Unfortunately, the catalysts chosen for the initial studies did not show any promise regarding enantioselectivity.
Recommended Citation
Yu, Arvin Zillion, "Diastereoselective Conjugate Radical Additions to ~-Pyrones" (2009). Chemistry and Biochemistry. 90.
https://digitalcommons.ndsu.edu/chem-biochem/90
Rights
NDSU policy 190.6.2
Rights Link
https://www.ndsu.edu/fileadmin/policy/190.pdf
Handle Identifier
https://hdl.handle.net/10365/33800